Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO cgh l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0746721	0.1254175	0.5579465
Weighted median	23	-0.0275028	0.0599206	0.6462435
Inverse variance weighted	23	0.0104562	0.0485038	0.8293187
Simple mode	23	-0.0841894	0.0867495	0.3423529
Weighted mode	23	-0.0506079	0.0638589	0.4365341

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.77746	21	0.0487437
Inverse variance weighted	33.62619	22	0.0535918

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0052273	0.0070887	0.469036

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010211	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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