Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO cgc r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0467521	0.1482137	0.7555433
Weighted median	23	0.0691466	0.0682479	0.3109801
Inverse variance weighted	23	0.0494331	0.0565926	0.3823954
Simple mode	23	0.2279945	0.1566240	0.1596036
Weighted mode	23	0.2507682	0.1565272	0.1234014

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	45.77813	21	0.0013675
Inverse variance weighted	45.77897	22	0.0021111

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0001646	0.0083773	0.9845064

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014353	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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