Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO cgc l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0619469	0.1306604	0.6403169
Weighted median	23	-0.0495739	0.0674140	0.4621173
Inverse variance weighted	23	0.0170250	0.0500554	0.7337642
Simple mode	23	-0.0635817	0.1402411	0.6547197
Weighted mode	23	-0.0814489	0.0909418	0.3801530

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.57619	21	0.0243852
Inverse variance weighted	35.81254	22	0.0318004

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0027584	0.0073851	0.7125116

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010909	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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