Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO atr r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0467392	0.1177539	0.6954291
Weighted median	23	-0.0318413	0.0571056	0.5771265
Inverse variance weighted	23	0.0049596	0.0452046	0.9126351
Simple mode	23	0.0079940	0.1080225	0.9416765
Weighted mode	23	-0.0437100	0.0669744	0.5207520

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.89407	21	0.1165680
Inverse variance weighted	29.20710	22	0.1390425

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0031746	0.0066556	0.6383055

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008855	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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