Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO ar r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1460830	0.1033628	0.1722184
Weighted median	23	0.0880415	0.0556087	0.1133682
Inverse variance weighted	23	0.0435939	0.0405425	0.2822568
Simple mode	23	0.0430809	0.0886601	0.6318351
Weighted mode	23	0.0837703	0.0597252	0.1746922

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.26313	21	0.3844852
Inverse variance weighted	23.49333	22	0.3743367

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0062933	0.0058422	0.293602

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007493	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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