Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO ar l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0053302	0.1134854	0.9629825
Weighted median	23	-0.0535019	0.0556377	0.3362440
Inverse variance weighted	23	0.0108845	0.0433569	0.8017790
Simple mode	23	-0.0572270	0.1054491	0.5927937
Weighted mode	23	-0.0641240	0.0662073	0.3433059

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.83744	21	0.1762989
Inverse variance weighted	26.86823	22	0.2162739

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0009957	0.0064143	0.8781267

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008165	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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