Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD unc r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2739034	0.1398814	0.0636346
Weighted median	23	0.2166887	0.0577534	0.0001755
Inverse variance weighted	23	0.2779182	0.0534112	0.0000002
Simple mode	23	0.1214643	0.0981817	0.2290789
Weighted mode	23	0.2031366	0.0645256	0.0046678

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.77762	21	0.0059730
Inverse variance weighted	40.77951	22	0.0087532

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0002465	0.0079064	0.9754191

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0027557	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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