Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD unc l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2643644	0.1395176	0.0719651
Weighted median	23	0.2263919	0.0576825	0.0000868
Inverse variance weighted	23	0.2365730	0.0533301	0.0000092
Simple mode	23	0.2409172	0.0801845	0.0065257
Weighted mode	23	0.2011174	0.0660999	0.0059731

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.56440	21	0.0063448
Inverse variance weighted	40.65486	22	0.0090558

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017066	0.0078859	0.8307592

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0023329	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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