Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD str r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2500965	0.1631864	0.1403065
Weighted median	23	0.1874617	0.0614822	0.0022957
Inverse variance weighted	23	0.2236844	0.0623545	0.0003341
Simple mode	23	0.1801143	0.1025345	0.0928944
Weighted mode	23	0.1481313	0.0651136	0.0330066

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	55.49621	21	5.98e-05
Inverse variance weighted	55.57792	22	9.83e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0016218	0.0092236	0.8621067

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0026682	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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