Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD str l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2811759	0.1456757	0.0672052
Weighted median	23	0.2347683	0.0599420	0.0000898
Inverse variance weighted	23	0.2292809	0.0558208	0.0000400
Simple mode	23	0.1832640	0.0950715	0.0669082
Weighted mode	23	0.2116473	0.0661172	0.0041214

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	44.22670	21	0.0021852
Inverse variance weighted	44.54215	22	0.0030323

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0031867	0.008234	0.7026388

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0023836	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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