Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD slf r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2367620	0.1796809	0.2018059
Weighted median	23	0.1859773	0.0584846	0.0014731
Inverse variance weighted	23	0.2602605	0.0686384	0.0001496
Simple mode	23	0.2185586	0.0923900	0.0272320
Weighted mode	23	0.1616064	0.0564240	0.0090165

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	67.28080	21	1.0e-06
Inverse variance weighted	67.34547	22	1.7e-06

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0014429	0.0101559	0.8883726

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.003372	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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