Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD slf l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2534808	0.1753072	0.1629589
Weighted median	23	0.1808150	0.0585528	0.0020146
Inverse variance weighted	23	0.2717900	0.0669559	0.0000492
Simple mode	23	0.1856813	0.0895806	0.0501103
Weighted mode	23	0.1808592	0.0572912	0.0045736

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	64.04584	21	3.1e-06
Inverse variance weighted	64.08510	22	5.4e-06

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011243	0.0099087	0.9107404

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0033944	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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