Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD ptr r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3263782	0.1302741	0.0205407
Weighted median	23	0.1993590	0.0567801	0.0004463
Inverse variance weighted	23	0.2225023	0.0506231	0.0000111
Simple mode	23	0.2415999	0.0983066	0.0223357
Weighted mode	23	0.2133677	0.0579400	0.0013039

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.36752	21	0.0257207
Inverse variance weighted	36.63133	22	0.0259550

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0063786	0.0073633	0.3961385

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0020845	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8