Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD ptr l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3488600	0.1112944	0.0050074
Weighted median	23	0.2671331	0.0605952	0.0000104
Inverse variance weighted	23	0.2296320	0.0438441	0.0000002
Simple mode	23	0.2760361	0.0940968	0.0076892
Weighted mode	23	0.2852831	0.0725366	0.0007102

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.81318	21	0.2136623
Inverse variance weighted	27.47817	22	0.1936254

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0073213	0.0062906	0.2575402

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018707	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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