Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD ml r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0957258	0.1018953	0.3581795
Weighted median	23	0.0360837	0.0585901	0.5379825
Inverse variance weighted	23	0.0706193	0.0392326	0.0718577
Simple mode	23	0.0217273	0.1009291	0.8315379
Weighted mode	23	0.0217273	0.0810241	0.7910759

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.63601	21	0.4207383
Inverse variance weighted	21.70984	22	0.4773177

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0015417	0.0057593	0.7915543

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000756	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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