Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD ml l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0049439	0.1388002	0.9719226
Weighted median	23	0.1078643	0.0596070	0.0703593
Inverse variance weighted	23	0.0635939	0.0533596	0.2333401
Simple mode	23	0.1848392	0.1166710	0.1274012
Weighted mode	23	0.1107703	0.0772485	0.1656486

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	40.14679	21	0.0071370
Inverse variance weighted	40.69695	22	0.0089525

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0042086	0.0078452	0.597284

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013127	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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