Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD mcp

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1826044	0.1287266	0.1707029
Weighted median	23	0.1310179	0.0650574	0.0440220
Inverse variance weighted	23	0.0527202	0.0505385	0.2968700
Simple mode	23	0.1390433	0.1200189	0.2590770
Weighted mode	23	0.1803114	0.0909864	0.0601396

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.53188	21	0.0317590
Inverse variance weighted	36.50775	22	0.0267698

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0079756	0.0072758	0.2854151

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011609	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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