Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD ilf l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2533636	0.1574021	0.1224030
Weighted median	23	0.2868181	0.0641749	0.0000078
Inverse variance weighted	23	0.3276934	0.0604747	0.0000001
Simple mode	23	0.2425546	0.0998053	0.0236979
Weighted mode	23	0.2330356	0.0664693	0.0019956

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	51.63261	21	0.0002153
Inverse variance weighted	52.27973	22	0.0002860

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0045642	0.0088967	0.6132865

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0036974	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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