Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD ifo r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2300115	0.1676726	0.1846082
Weighted median	23	0.2593442	0.0631764	0.0000404
Inverse variance weighted	23	0.3037778	0.0643677	0.0000024
Simple mode	23	0.2728371	0.0947849	0.0087253
Weighted mode	23	0.2135802	0.0651449	0.0034323

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	58.58893	21	2.08e-05
Inverse variance weighted	59.22626	22	2.91e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0045296	0.0094772	0.6376221

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0036102	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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