Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD ifo l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2802824	0.1644405	0.1030474
Weighted median	23	0.2464658	0.0603828	0.0000447
Inverse variance weighted	23	0.2992176	0.0628098	0.0000019
Simple mode	23	0.2074788	0.0941521	0.0383147
Weighted mode	23	0.2119025	0.0594943	0.0017451

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	56.35250	21	4.48e-05
Inverse variance weighted	56.39449	22	7.51e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011627	0.0092945	0.9016358

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0034701	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8