Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD fmi

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2314008	0.1564161	0.1538810
Weighted median	23	0.1686754	0.0611308	0.0057933
Inverse variance weighted	23	0.2088354	0.0597580	0.0004746
Simple mode	23	0.1822442	0.0966709	0.0726794
Weighted mode	23	0.1425073	0.0668382	0.0444073

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	50.98462	21	0.0002657
Inverse variance weighted	51.04426	22	0.0004230

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0013856	0.0088409	0.8769553

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0024046	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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