Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD fma

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0285119	0.1270909	0.8246588
Weighted median	23	0.0506618	0.0574626	0.3779670
Inverse variance weighted	23	0.1281810	0.0505565	0.0112318
Simple mode	23	0.0736549	0.1147942	0.5277450
Weighted mode	23	0.0381236	0.0696039	0.5893971

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.65801	21	0.0394112
Inverse variance weighted	36.53354	22	0.0265979

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0096217	0.0071834	0.1947437

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014303	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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