Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD cst r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3214754	0.1003855	0.0042795
Weighted median	23	0.1740457	0.0564704	0.0020557
Inverse variance weighted	23	0.1353115	0.0392320	0.0005627
Simple mode	23	0.1396866	0.0976427	0.1665990
Weighted mode	23	0.1627377	0.0625801	0.0163285

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.87698	21	0.7185362
Inverse variance weighted	20.93608	22	0.5246914

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0114315	0.005674	0.0569166

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009949	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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