Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD cst l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2260781	0.1322452	0.1020890
Weighted median	23	0.2022613	0.0611060	0.0009329
Inverse variance weighted	23	0.1892782	0.0506049	0.0001838
Simple mode	23	0.2453643	0.1174299	0.0484453
Weighted mode	23	0.1720410	0.0701683	0.0226177

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.44572	21	0.0194734
Inverse variance weighted	36.60434	22	0.0261310

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0022597	0.0074748	0.7653875

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018144	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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