Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD cgh r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1467271	0.1003836	0.1586372
Weighted median	23	0.2014565	0.0557354	0.0003009
Inverse variance weighted	23	0.1756089	0.0392317	0.0000076
Simple mode	23	0.2012386	0.1005417	0.0578176
Weighted mode	23	0.2071297	0.0663281	0.0049536

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.42766	21	0.5577263
Inverse variance weighted	19.52537	22	0.6127022

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017735	0.0056739	0.7576871

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011988	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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