Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD cgh l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1822596	0.1003852	0.0837387
Weighted median	23	0.1915475	0.0561853	0.0006515
Inverse variance weighted	23	0.1360363	0.0392321	0.0005254
Simple mode	23	0.2301339	0.0963899	0.0259827
Weighted mode	23	0.1938728	0.0655659	0.0072857

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.86162	21	0.7194596
Inverse variance weighted	17.11187	22	0.7571574

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0028384	0.005674	0.6221049

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008829	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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