Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD cgc r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2574802	0.1418163	0.0837408
Weighted median	23	0.1429175	0.0576174	0.0131214
Inverse variance weighted	23	0.1986957	0.0544096	0.0002604
Simple mode	23	0.1692450	0.0900070	0.0733656
Weighted mode	23	0.1434882	0.0555052	0.0168923

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.91077	21	0.0043177
Inverse variance weighted	42.31550	22	0.0057233

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0036097	0.0080157	0.6570907

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.002059	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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