Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD cgc l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2183442	0.1592364	0.1847905
Weighted median	23	0.1832887	0.0593026	0.0019966
Inverse variance weighted	23	0.2567698	0.0608991	0.0000248
Simple mode	23	0.1356209	0.1016811	0.1959187
Weighted mode	23	0.1459300	0.0629362	0.0300933

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	52.84016	21	0.0001450
Inverse variance weighted	53.01309	22	0.0002262

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0023595	0.0090003	0.7957519

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0029036	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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