Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD atr r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2888572	0.1340627	0.0429517
Weighted median	23	0.1629835	0.0568751	0.0041617
Inverse variance weighted	23	0.2106937	0.0516749	0.0000456
Simple mode	23	0.1596273	0.0816983	0.0635480
Weighted mode	23	0.1638141	0.0629284	0.0162306

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.45398	21	0.0149221
Inverse variance weighted	38.16954	22	0.0175353

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0047997	0.0075775	0.5333035

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0020299	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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