Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD atr l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2132029	0.1150487	0.0779653
Weighted median	23	0.1776440	0.0572679	0.0019223
Inverse variance weighted	23	0.2094852	0.0439297	0.0000019
Simple mode	23	0.1599651	0.0959801	0.1097597
Weighted mode	23	0.1738811	0.0659185	0.0150288

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.58277	21	0.1523858
Inverse variance weighted	27.58439	22	0.1898667

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002283	0.0065028	0.9723271

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0016995	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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