Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD ar r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2349590	0.1580406	0.1519548
Weighted median	23	0.1079293	0.0610216	0.0769426
Inverse variance weighted	23	0.1981199	0.0604359	0.0010448
Simple mode	23	0.0606408	0.0933821	0.5228133
Weighted mode	23	0.0820904	0.0631074	0.2067857

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	52.05033	21	0.0001879
Inverse variance weighted	52.20928	22	0.0002925

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0022621	0.0089327	0.8025468

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.002354	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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