Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MD ar l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1707077	0.1367440	0.2256334
Weighted median	23	0.1037556	0.0599204	0.0833522
Inverse variance weighted	23	0.1921530	0.0522487	0.0002354
Simple mode	23	0.4876054	0.1714863	0.0094538
Weighted mode	23	0.0888093	0.0736908	0.2409450

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.96689	21	0.0099051
Inverse variance weighted	39.02076	22	0.0140349

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0013168	0.007729	0.8663437

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019092	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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