Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 unc r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2189696	0.1333331	0.1154244
Weighted median	23	0.1810567	0.0576878	0.0016978
Inverse variance weighted	23	0.2480702	0.0509776	0.0000011
Simple mode	23	0.0963539	0.0894047	0.2928315
Weighted mode	23	0.1632354	0.0597863	0.0122170

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.04734	21	0.0166247
Inverse variance weighted	37.14652	22	0.0227947

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017869	0.0075362	0.8148681

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0023367	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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