Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 unc l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2655019	0.1283356	0.0510965
Weighted median	23	0.1672706	0.0559935	0.0028143
Inverse variance weighted	23	0.2059676	0.0492969	0.0000294
Simple mode	23	0.1483717	0.0818692	0.0836115
Weighted mode	23	0.1630078	0.0606761	0.0134798

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.32215	21	0.0334625
Inverse variance weighted	34.73727	22	0.0412638

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0036557	0.0072538	0.6195247

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0018873	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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