Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 str r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2055717	0.1550758	0.1992063
Weighted median	23	0.1597421	0.0604297	0.0082069
Inverse variance weighted	23	0.2152338	0.0592182	0.0002784
Simple mode	23	0.2455416	0.1101433	0.0363229
Weighted mode	23	0.1494309	0.0641273	0.0293656

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	50.11580	21	0.0003515
Inverse variance weighted	50.12674	22	0.0005638

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0005933	0.0087651	0.9466735

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0024302	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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