Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 str l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2865195	0.1517212	0.0728570
Weighted median	23	0.2353669	0.0605186	0.0001006
Inverse variance weighted	23	0.2290928	0.0581638	0.0000819
Simple mode	23	0.2066909	0.0975320	0.0455960
Weighted mode	23	0.2298236	0.0700850	0.0034268

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	47.97334	21	0.0006934
Inverse variance weighted	48.35962	22	0.0009724

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0035264	0.0085757	0.6850892

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0024973	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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