Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 slf r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1887232	0.1726898	0.2868405
Weighted median	23	0.1393189	0.0584068	0.0170644
Inverse variance weighted	23	0.2235438	0.0660117	0.0007081
Simple mode	23	0.0754490	0.0902201	0.4119910
Weighted mode	23	0.1140689	0.0710759	0.1227786

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	62.14677	21	6.00e-06
Inverse variance weighted	62.28878	22	1.02e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0021382	0.0097608	0.8287203

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0028696	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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