Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 slf l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2586636	0.1683341	0.1393202
Weighted median	23	0.1479909	0.0596907	0.0131642
Inverse variance weighted	23	0.2443635	0.0642858	0.0001440
Simple mode	23	0.1628037	0.0849716	0.0684530
Weighted mode	23	0.1578018	0.0575121	0.0118511

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	59.05132	21	1.78e-05
Inverse variance weighted	59.07527	22	3.06e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0008781	0.0095146	0.9273423

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0029641	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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