Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 ptr r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3221175	0.1272681	0.0194287
Weighted median	23	0.1971224	0.0579611	0.0006715
Inverse variance weighted	23	0.2125311	0.0495965	0.0000183
Simple mode	23	0.2217903	0.0853576	0.0164048
Weighted mode	23	0.1979369	0.0581717	0.0025552

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.75391	21	0.0384976
Inverse variance weighted	35.16048	22	0.0372748

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0067292	0.0071935	0.3601823

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0019545	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8