Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 ptr l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3805216	0.1084963	0.0020963
Weighted median	23	0.2451577	0.0600443	0.0000445
Inverse variance weighted	23	0.2167433	0.0439996	0.0000008
Simple mode	23	0.2399228	0.0996191	0.0248429
Weighted mode	23	0.2976721	0.0739515	0.0005672

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.53160	21	0.2680202
Inverse variance weighted	27.67333	22	0.1867613

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.010057	0.0061325	0.1159098

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0017633	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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