Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 ml r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1254005	0.1003868	0.2253469
Weighted median	23	0.1092099	0.0566174	0.0537422
Inverse variance weighted	23	0.0797289	0.0392326	0.0421321
Simple mode	23	0.0725168	0.0936576	0.4470094
Weighted mode	23	0.1373100	0.0729919	0.0732501

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.22226	21	0.5708848
Inverse variance weighted	19.46656	22	0.6163693

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0028045	0.005674	0.6262496

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000715	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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