Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 ml l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0325646	0.1323899	0.8080898
Weighted median	23	0.1109565	0.0593368	0.0614919
Inverse variance weighted	23	0.0823748	0.0507506	0.1045614
Simple mode	23	0.1310425	0.1158135	0.2700300
Weighted mode	23	0.0992148	0.0729227	0.1874338

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	36.52388	21	0.0190796
Inverse variance weighted	36.81446	22	0.0247887

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0030586	0.0074829	0.6868642

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012491	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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