Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 mcp

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1851663	0.1360175	0.1878350
Weighted median	23	0.0999536	0.0666066	0.1334445
Inverse variance weighted	23	0.0690318	0.0529890	0.1926577
Simple mode	23	0.1032931	0.1149323	0.3785283
Weighted mode	23	0.1635927	0.0985769	0.1111956

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.55461	21	0.0110885
Inverse variance weighted	40.13430	22	0.0104276

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0071312	0.0076879	0.364158

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013099	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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