Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 ilf r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3341303	0.1492995	0.0361877
Weighted median	23	0.2379386	0.0558427	0.0000204
Inverse variance weighted	23	0.3081248	0.0570544	0.0000001
Simple mode	23	0.2059241	0.0813144	0.0189709
Weighted mode	23	0.2255922	0.0580546	0.0007964

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	46.45369	21	0.0011117
Inverse variance weighted	46.53290	22	0.0016878

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0015969	0.0084388	0.8517278

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0032783	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8