Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 ilf l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2820315	0.1560693	0.0850977
Weighted median	23	0.2578425	0.0603891	0.0000196
Inverse variance weighted	23	0.3103947	0.0596457	0.0000002
Simple mode	23	0.2124484	0.0945103	0.0349376
Weighted mode	23	0.2218004	0.0639115	0.0021728

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	50.76213	21	0.0002855
Inverse variance weighted	50.85636	22	0.0004487

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0017417	0.0088214	0.845385

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.003437	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8