Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 ifo r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2669802	0.1611883	0.1125232
Weighted median	23	0.2334340	0.0586350	0.0000686
Inverse variance weighted	23	0.2927300	0.0615888	0.0000020
Simple mode	23	0.2675994	0.0922795	0.0083077
Weighted mode	23	0.2104271	0.0635843	0.0031900

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	54.14471	21	9.41e-05
Inverse variance weighted	54.22237	22	1.53e-04

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0015812	0.0091107	0.86388

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0033289	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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