Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 ifo l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3178216	0.1635471	0.0655041
Weighted median	23	0.1925841	0.0590703	0.0011131
Inverse variance weighted	23	0.2769892	0.0625548	0.0000095
Simple mode	23	0.1473871	0.0927146	0.1261742
Weighted mode	23	0.1788458	0.0599162	0.0068288

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	55.74186	21	5.51e-05
Inverse variance weighted	55.93714	22	8.73e-05

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025073	0.009244	0.7888562

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0032042	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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