Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 fmi

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2628444	0.1592009	0.1136108
Weighted median	23	0.1369903	0.0621723	0.0275668
Inverse variance weighted	23	0.2176766	0.0609239	0.0003530
Simple mode	23	0.1496419	0.1004804	0.1506145
Weighted mode	23	0.1287989	0.0683278	0.0727058

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	52.81764	21	0.000146
Inverse variance weighted	53.05659	22	0.000223

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0027735	0.0089984	0.7609453

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0025397	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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