Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 fma

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0244398	0.1272860	0.8495816
Weighted median	23	0.0399397	0.0585207	0.4949306
Inverse variance weighted	23	0.1382573	0.0507828	0.0064786
Simple mode	23	0.0492266	0.1176855	0.6797907
Weighted mode	23	0.0174824	0.0623653	0.7818492

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.76124	21	0.0384286
Inverse variance weighted	36.86134	22	0.0244979

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0099904	0.0071944	0.179498

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014931	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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