Two sample MR report

Telomere_length against IDP dMRI ProbtrackX L3 cst r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.3075697	0.1003857	0.0058929
Weighted median	23	0.1661413	0.0570967	0.0036163
Inverse variance weighted	23	0.1555583	0.0392321	0.0000734
Simple mode	23	0.1347550	0.0862524	0.1324808
Weighted mode	23	0.1510417	0.0645528	0.0287725

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.32128	21	0.8064925
Inverse variance weighted	18.02766	22	0.7043469

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0093343	0.005674	0.1148343

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010227	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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